COS Attenuates AFB1-Induced Liver Injury in Medaka through Inhibition of Histopathological Damage and Oxidative Stress

Aflatoxin B1 (AFB1) –induced liver damage may be treated with chitosan oligosaccharide (COS), a small-molecular–weight excellent bioactivity and antioxidant potential. Hepatotoxicity induced by AFB1 single acute exposure (ASAE) has been theoretically established but the mechanism of toxicity in aquatic models less studied. In this paper, model injury Japanese medaka (Oryzias latipes) after ASAE for 72 h healing following COS intervention were developed. The different effects interventions analyzed at phenotypic genetic levels. results showed that reduced body weight hepatopancreatic somatic indices (HSI) medaka. Moreover, AFB1–induced histopathological oxidative stress concentration–dependent symptoms attenuated to some extent addition drug COS, effect high concentrations was almost identical silymarin (SIL). Using RNA–Seq technique, reduces number differentially expressed genes (DEGs) brought about AFB1. Among associated tumors, hepatocellular carcinoma hepatitis aurka, thbs1, serpine1, fabp7, dusp5 also validated Q-PCR corresponding trends. conclusion, can cause therapeutic effect, these impacted have potential become targets disease.